Human Sera
Cayman Chemical Psoala coylfola Bakucol 50mg
A natural meroterpene that has retinol-like effects on gene expression and properties of the skin; has antioxidant and antibacterial actions; inhibits DNA polymerase and UDP-glucuronosyltransferase 2B7 (IC50 = 41 µM)
Cayman Chemical 5-DIhydroprogesteron 100mg
A progesterone receptor agonist and metabolite of progesterone; inhibits spontaneous contractions in isolated rat uterus at 10 UG/ml; a negative modulator of homooligomeric ρ1 subunit-containing GABAAreceptors expressed in X. laevis oocytes (IC50 = 5.02 µM); plasma levels decrease at the onset of spontaneous human labor
Cayman Chemical TRx0237mesylate 50mg
An inhibitor of tau aggregation; inhibits tau-tau binding (IC50 = 238 µM) and tau aggregation in 3T6H cells expressing human tau (EC50 = 0.19 µM); increases hippocampal ACh and synaptophysin levels, as well as increases mitochondrial complex IV activity, decreases tau pathology, and reverses deficits in spatial learning in the L1 transgenic mouse model of Alzheimer’s disease
Cayman Chemical OsIlodrostat 50mg
An aldosterone synthase inhibitor; selective for human aldosterone synthase over rat aldosterone synthase (IC50 = 160 nM); inhibits increases in plasma aldosterone levels induced by angiotensin II or ACTH in rats (ED50s = 0.6 and 1.1 mg/kg, respectively); reduces mean arterial pressure and prolongs survival in rats expressing human renin and angiotensinogen, a double-transgenic model of angiotensin II-dependent hypertension, in a dose-dependent manner
Cayman Chemical AlendronATsodIum hydrAT 100mg
An FPP synthase inhibitor (IC50 = 50 nM for the recombinant human enzyme); inhibits bone resorption in a pit formation assay using isolated rat osteoclasts (IC50 = 2 nM); reduces angiotensin II-induced collagen I synthesis in isolated rat cardiac fibroblasts at 3 and 10 µM; prevents femoral bone mineral density loss in ovariectomized rats at 5 mg/kg
Cayman Chemical SuberylglycIn 100mg
A glycine-conjugated form of suberic acid; urinary levels are increased in patients with MCAD deficiency
Cayman Chemical DaunorubIcInon 50mg
An aglcyone form of the antitumor antibiotic daunorubicin; has been used as a starting material in the synthesis of anticancer agents
Cayman Chemical ResorcInolnaphthaleIn 50mg
Increases the activity of angiotensin-converting enzyme 2 (ACE2) in vitro (EC50 = 19.5 μM)
Cayman Chemical MelItracenhydrochlorIde 100mg
A thymoleptic and tricyclic antidepressant; inhibits 5-HT uptake in rat brain synaptosomes (IC50 = 670 nM); increases the lethality of yohimbine in mice at 20 and 40 mg/kg
Cayman Chemical Rsperdon 50mg
An atypical antipsychotic; binds to dopamine D2 receptors (Ki = 3 nM) and the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 0.12 nM); also binds to dopamine D4, α1- and α2-adrenergic, 5-HT1C, 5-HT1D, and histamine H1 receptors (Kis = 7, 0.81, 7.3, 47, 52, and 2.1 nM, respectively); attenuates deficits in prepulse inhibition of the acoustic startle response, but not deficits in social interaction, in a rat neonatal ventral hippocampal lesion model of schizophrenia at 0.1 mg/kg per day
Cayman Chemical HederagenIn 100mg
A triterpene saponin with diverse biological activities; increases production of ROS, reduces colony formation, and induces apoptosis in cisplatin-resistant HNC cells; suppresses tumor growth in a cisplatin-resistant HNC mouse xenograft model at 50, 100, and 200 mg/kg; reduces aortic atherosclerotic lesion area, serum cholesterol and LDL levels, and iNOS protein levels in a rat model of atherosclerosis; reduces ethanol-induced production of TNF-α, IL-6, and COX-2, ALDH2 mRNA expression, and liver damage in a rat model of alcohol-induced hepatotoxicity at 50 mg/kg; induces autophagy and inhibits oligomerization of α-synuclein in a mouse model of MPTP-induced Parkinson's disease
Cayman Chemical GInsenosIde Rb3 50mg
A steroid glycoside with diverse biological activities; inhibits OGD-induced JNK-mediated activation of NF-κB and apoptosis in H9c2 mouse cardiac myoblasts; reduces myocardial apoptosis and production of ROS in a rat model of myocardial ischemia-reperfusion injury at 20 mg/kg; prevents increases in serum creatinine, BUN, MDA, and decreases in SOD activity and GSH levels, as well as inhibits renal cell apoptosis in a mouse model of cisplatin-induced nephrotoxicity at 10 and 20 mg/kg; decreases the abundance of cancer cachexia-associated gut microbiota and the number of polyps in the ApcMin/+ mouse model of colon cancer; decreases immobility time in the forced swim and tail suspension tests in mice
Cayman Chemical MethylatropInItrate 50mg
A muscarinic acetylcholine antagonist (IC50 = 50 = 5.5 UG/kg); reduces salivation, induces mydriasis, and increases heart rate in dogs
Cayman Chemical MolsIdomIn 100mg
Molsidomine is a NO-releasing prodrug. Liver esterases convert molsidomine to the active metabolite, SIN-1 (half-life in plasma is 1-2 hours), which then releases NO.
Cayman Chemical SIN-1chlorIde 100mg
Active metabolite of molsidomine that acts as a potent vasorelaxant and inhibitor of platelet aggregation; produces both NO and superoxide to generate peroxynitrite under physiological conditions